The hunt is set for Dec. 1-5 in Horry, Georgetown and Williamsburg counties, the SCDNR said.
Ten tags will be issued for each county through a random drawing.
Those selected for the hunt also will be required to purchase a tag, which costs $25 for residents and $100 for nonresidents, the agency said.
Nonresidents must also provide evidence of purchasing a hunting license and big-game permit in order to apply. Only those selected by a random drawing will be able to purchase a tag and attempt to take a bear.
Tags will only be valid for one of the three counties so applicants will be asked to rank the counties in order of preference.
Selected hunters will be allowed to hunt on wildlife management areas in the county selected as long as they possess valid WMA permits.
Bears may be taken on private lands if hunters have permission from landowners or hunting-lease holders.