If you plan to shoot more than one type and weight of ammunition, you will likely find that you will have to adjust your scope. The weight variation has a significant effect on the point of impact.
When shooting at animals as small as squirrels, a small variation is the difference between a hit and miss, or a kill shot versus losing an injured animal.
It is good to experiment with different weights and types of ammo to see what your gun shoots best, but it will be necessary to make scope adjustments, or you will be guessing or using “Kentucky windage” to compensate for the changes.
In the heat of the hunt, it is easy to forget to make a mental adjustment by holding low or high. Better to be sure and make the proper scope adjustment.